Droplet Paired-Tag Kits

Catalog

Product Catalogue # Platform Size List Price Link
Droplet Paired-Tag DP8101 10X Chromium 8 Reactions $2470 Order
Droplet Paired-Tag DP16101 10X Chromium 16 Reactions $4098 Order

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What It Is

Flow diagram of Droplet Paired-Tag process

Droplet Paired-Tag is an innovative single-cell multiomic assay that simultaneously measures RNA expression and DNA-modifying proteins in the same cell. By tagging histone post-translational modifications (PTMs) - or other proteins such as transcription factors (TFs) - in individual nuclei, the Droplet Paired-Tag Reagent Kit offers a comprehensive snapshot of gene regulation. Designed to integrate with the 10x Chromium® system, this workflow captures both transcriptomic and epigenetic information in a single run, eliminating the need for multiple separate assays.

What You Need to Get Started

  • Antibody: Validated primary antibody for target of interest
  • Single-Cell Platform: 10x Genomics Chromium
  • Reagents: 10x Genomics Multiome Kit
  • Sequencing: Illumina-compatible sequencing system

Key Advantages

Scientists evaluating and approving single-cell Paired-Tag data
  • Comprehensive Epigenetic Profiling: Assess histone states and TF binding, going far beyond open-chromatin or methylation alone.
  • Cell-Specific Insights: RNA-based annotation lets you identify and profile rare cell populations without sorting.
  • Effortless Integration: Seamlessly aligns with leading single-cell barcoding systems (e.g., 10x Genomics ATAC or Multiome kits) for easy adoption.

Performance & Data

Recovery and average Paired-Tag UMI for Brain and PBMC data
  • 📈 Throughput & Coverage: Capture thousands of cells in a single run, with high UMI counts for RNA and DNA profiling: 5000+ UMI/cell for broad marks.
  • 🧬 Versatility: Compatible with fresh, frozen, and cryopreserved samples, supporting histone PTMs, chromatin remodelers, and transcription factors
  • 🔍Robustness: Bulk and single-cell profiling correlations demonstrate high reproducibility, ensuring confidence in results.

Get Started

Ready to unlock the combined power of epigenetics and transcriptomics in a single cell? Each Droplet Paired-Tag Kit provides all core reagents for up to 8 reactions—enabling multi-target or well-characterized experiments with up to 80,000 recovered cells. If you’re new to targeted single-cell epigenetics, we also offer Droplet Paired-Tag as a Service. Contact us today to streamline your research and gain deeper insights into the regulatory mechanisms behind disease, development, and cellular diversity.

  • 📦 Order Now: Select your desired Droplet Paired-Tag Kit
  • 📖 Read the Protocol:Download Protocol
  • 💡 Need Help? Contact Support
  • 🚀 Accelerate your research with Droplet Paired-Tag!

Image of Epigenome Technologies shipping boxes for Droplet Paired-Tag

Droplet Paired-Tag: 8 Reaction Kit: Ideal for smaller-scale projects or pilot studies, this kit provides the core reagents for eight single-cell chromatin and transcriptomic profiling experiments. Compatible with 10x Genomics ATAC or Multiome systems, it captures up to 80,000 cells total (10,000 cells per reaction), streamlining your workflow without sacrificing data quality.

Image of Epigenome Technologies shipping boxes for Droplet Paired-Tag

Droplet Paired-Tag: 16 Reaction Kit: Built for higher-throughput studies, this kit supports sixteen reactions and can process up to 160,000 cells in total. It features all necessary reagents to profile histone modifications or transcription factors in tandem with single-cell RNA, allowing for comprehensive multiomic insights across larger sample sets.

Paired-Tag Services

If you’re new to targeted single-cell epigenetics, we also provide Single-Cell Paired-Tag as a Service — simply send us your samples, and our team will handle everything from assay setup to data delivery. Contact us today to discover how Single-Cell CUT&Tag can shed light on the dynamic chromatin landscapes underlying your research questions.