ChIP-seq
End-to-end ChIP-seq Services
- Full project: From chromatin preparation through analysis
- Library QC metrics and sequencing-ready material or FASTQ delivery
- Detailed report with QC, peak calls, and biological insights
Foundational Technologies for Single-Cell Multi-Omics
Epigenome Technologies develops and applies proprietary single-cell profiling methods that simultaneously capture chromatin state, transcriptional activity, or histone dynamics from individual cells. Our flagship Paired-Tag and scCUT&Tag technologies unlock regulatory mechanisms that drive cellular heterogeneity, disease progression, and treatment responses.
Paired-Tag: Simultaneous RNA and Chromatin Profiling
What It Is
Paired-Tag is a patented single-cell multiomic method that simultaneously captures full-length transcripts and histone modifications, transcription factors, or chromatin-associated proteins from the same cell. The dual readout reveals direct links between chromatin state and gene expression without requiring computational integration.
Key Advantages
- True dual-modality: RNA and epigenetics captured simultaneously, not computationally integrated.
- Direct chromatin-transcript linkage: See which genes are active when regulatory marks are present.
- Rare cell discovery: RNA-based clustering identifies populations; epigenetics characterizes their regulatory programs.
- 10x-compatible: Works seamlessly with Chromium platforms and existing workflows.
Next Steps
- Product kits: Order Droplet Paired-Tag or Multiplex Paired-Tag reagents for in-house profiling.
- Full-service: Paired-Tag services handle sample prep through data delivery.
- Learn more: Visit the detailed Paired-Tag technology page.
scCUT&Tag: Single-Cell Profiling of Chromatin State or TF Binding.
What It Is
Single-Cell CUT&Tag is an ultra-sensitive epigenome profiling method that maps histone modifications, transcription factors, or chromatin-associated proteins at single-cell resolution without requiring RNA data. By dedicating all sequencing depth to epigenetic targets, scCUT&Tag uncovers subtle chromatin heterogeneity and delivers unprecedented detail into regulatory landscapes.
Key Advantages
- Deep epigenetic coverage: No RNA barcode competition; higher per-cell depth for chromatin targets.
- No RNA requirement: Works with degraded samples, FFPE tissue, or when epigenetics is the sole focus.
- Streamlined workflow: Fewer library prep steps than multiomic approaches, reducing complexity and cost.
- Multiple platform compatibility: Adapts to 10x, BD Rhapsody, Fluent, Singleron, or custom barcoding.
Next Steps
- Product kits: Order scCUT&Tag kits for hands-on profiling.
- Full-service: scCUT&Tag services provide antibody validation through interpretive analysis.
- Learn more: Visit the detailed scCUT&Tag technology page.
Ready to Apply These Technologies?
Whether you need hands-on kits or full-service support, our team is here to help you succeed.
- Expert consultation on experimental design and antibody selection
- Comprehensive protocols and troubleshooting guidance
- Publication-ready data with rigorous quality control