Bulk & Single-Cell Combined Services
Unlock the Power Multiscale Epigenetics - Without the Benchwork
Our Bulk & Single-Cell Epigenetic Services combine the cost-effectiveness and speed of bulk CUT&Tag with the fine-grained resolution of single-cell profiling (either single-cell CUT&Tag or Paired-Tag). Whether you need a large sample screen, detailed antibody optimization, or an integrated experiment featuring both approaches, we offer end-to-end support to ensure you capture the complete regulatory picture.
| Name | Cat. No | Price |
|---|---|---|
| Joint Bulk & scCUT&Tag | SJBCS201 | Request Quote |
| Joint Bulk & Paired-Tag | SJPTS202 | Request Quote |
Why Epigenome Technologies?
Protocol Inventors: Recognized through high-impact publications and collaborations as pioneers of targeted multi-omics.
Proven Track Record: Hundreds of processed samples of consistently high quality.
Leading Technology: Our scCUT&Tag approach is the best-proven method for cell-resolution CUT&Tag profiling.
Deep Expertise: Experience with wide variety of tissues and target types, we can ensure your experiment is set up for success.
Benefits of Both: Maximize Power on a Small Budget
- Bulk CUT&Tag provides cost-effective profiling of targets, enabling large sample-size experiments.
- Precision single-cell Paired-Tag can reveal which cells drive the bulk differences.
- Combined profling lets you discover disrupted regulatory programs and cell drivers in the most cost-effective way.
Applications
- Complex Disease Models: Profile epigenetic factors to unravel cancer, autoimmunity, or neurodegeneration.
- Rare Cell Populations: Discover subtle epigenetic variations without expensive sorting.
- Drug Discovery & Validation: Use histone modification profiles to uncover new therapeutic targets.
- Biomarker Discovery: Identify gene-regulatory changes that correlate with treatment response or resistance.
Comprehensive Services Workflow
Consultation & Experimental Design
We review your sample types, target histone marks or TFs, and project goals to ensure the optimal protocol is selected.
Sample Prep & Library Construction
Our highly trained lab technicians handle the full workflow, from nuclei isolation and antibody staining, to single-cell library preparation. Quality control is incorporated into each step to ensure the robust production of ideal libraries. Your libraries can be delivered directly, or sequenced and delivered as sequence reads.
Sequencing & Data Generation
We partner with leading sequencing providers or work with your preferred facility, guaranteeing high-coverage data.
Quality Control & Initial Analysis
Our services include basic quality checks, including demultiplexing, alignment, and preliminary clustering, and QC metric generation, delivering data you can readily explore.
End-to-end Bioinformatics
For labs seeking deeper insights, we offer full downstream analysis—including differential expression, cluster annotation, cis‑regulatory element linking, and integrated RNA+epigenetic visualization—so you can jump straight to biological interpretation.
Deliverables
-
Processed fastQ Files Ready for your own pipelines, or integrated with standard tools like CellRanger and provided as Seurat/Scanpy objects.
-
Quality Control Reports Overview of library complexity, tagmentation quality, saturation, and cell recovery.
- Optional Bioinformatics Support Additional analysis or custom data visualization can be arranged upon request.